New Manuscript Published on the Anti-Arrhythmic Effects of Dantrolene in Human Hearts

In this study, published in AJP Heart and Circulatory Physiology, we investigated the anti-arrhythmic potential of Dantrolene, a ryanodine receptor inhibitor. We simulated two key aspects of structural heart disease, b-adrenergic stimulation and ryanodine receptor hyperactivity, in human heart models of ventricular slices and right ventricular outflow tract preparations. We demonstrate that dantrolene suppresses arrhythmogenic triggers and reverses arrhythmogenic substrates. This indicates the RyR2 inhibition in the heart could be a novel anti-arrhythmic therapy for structural heart disease.

You can read the paper here.