New paper in Science Advances: Battery-free, Light-powered Pacemaker may Improve Quality of Life for Heart Disease Patients
The Efimov lab has published a new study in collaboration with the Gutruf lab from the University of Arizona. The paper in Science Advances is on wireless, fully implantable cardiac stimulation and recording with on-device computation for closed-loop pacing and defibrillation.
The observation and control of cardiac function are essential to investigate cardiac physiology and pathophysiology. Current investigative strategies, however, require controlled in vivo environments to house studies that cannot replicate the natural physiology of freely roaming life. Here, we introduce a wireless battery-free device with onboard computation for real-time cardiac control with multisite stimulation enabling control over the entire rodent heart. Here, we achieved a strategy with chronic pacing, recording, and onboard computation in freely moving animals. This device class enabled investigation into new heart failure models and a platform for testing therapeutic paradigms in real time.
